Synthesis of 9E- and 9Z-locked retinoic acid analogs as ligands for RAR and RXR

DOI: 10.1248/cpb.42.2659

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2659 - 2661 (1994)

Update date:2022-07-31

Topics:

Authors:

Katsuta Katsuta

Aoyama Aoyama

Osone Osone

Wada Wada

Uchiyama

Kitamoto

Masushige

Kato Kato

Ito Ito

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Article abstract of DOI:10.1248/cpb.42.2659

New retinoic acid (RA) analogs 9E-locked-RA 3 and 9Z-locked-RA 4 were synthesized from dithiane 6 and β-cyclocitral 13, respectively. Both analogs behaved as agonistic ligands for a mixture of retinoic acid receptor (RAR) and retinoid X receptor (RXR).

Full text of DOI:10.1248/cpb.42.2659

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