Chemoselective reduction of functionalized 5-nitroisoxazoles: Synthesis of 5-amino- and 5-[hydroxy(tetrahydrofuran-2-yl)amino]isoxazoles

DOI: 10.1055/s-0033-1340827

Source and publish data:

Synthesis p. 1107 - 1113 (2014)

Update date:2022-07-30

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Authors:

Averina, Elena B.

Vasilenko, Dmitry A.

Samoilichenko, Yuri V.

Grishin, Yuri K.

Rybakov, Victor B.

Kuznetsova, Tamara S.

Zefirov, Nikolay S.

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Article abstract of DOI:10.1055/s-0033-1340827

Reduction by using SnCl₂ of easily accessible 5-nitroisoxazoles substituted with an electron-withdrawing group (EWG) has been studied. Whereas the reaction in ethanol yielded 5-aminoisoxazoles, performing the reaction in tetrahydrofuran gave pr

Full text of DOI:10.1055/s-0033-1340827

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