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Synthesis and biological activity of carboxyphenylquinolines and related compounds as new potent retinoids. Retinobenzoic acids. VII

DOI: 10.1248/cpb.42.2575

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2575 - 2581 (1994)

Update date:2022-07-30

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Authors:

EyrollesEyrolles

KawachiKawachi

KagechikaKagechika

HashimotoHashimoto

ShudoShudo

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Article abstract of DOI:10.1248/cpb.42.2575

A series of new quinoline, quinolone, and quinazolinedione derivatives was synthesized and tested for retinoid activity in the human promyelocytic cell line HL-60 differentiation assay. All the quinoline compounds exhibited significant activity, depending on the substituent on the heterocycle. However, the quinolone and quinazolinedione derivatives were poor inducers of the differentiation of the HL-60 cells, the activity depending strongly on the polarity of the molecule.

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Full text of DOI:10.1248/cpb.42.2575

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Products guided by the article

Product name:4-(6,6,9,9-Tetramethyl-4-oxo-1,4,6,7,8,9-hexahydro-benzo[g]quinolin-2-yl)-benzoic acid methyl ester

Cas No:163161-90-8

163161-90-8

R&D Labs maybe for 163161-90-8

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