Journal of Medicinal Chemistry p. 1666 - 1672 (1995)
Update date:2022-08-03
Topics:
Pettit, George R.
Singh, Sheo Bux
Boyd, Michael R.
Hamel, Ernest
Pettit, Robin K.
et al.
The antineoplastic constituents of Combretum caffrum (Eckl. and Zeyh) Kuntze (Combretaceae family), a species indigenous to South Africa, have been investigated.Subsequently we isolated a series of closely related bibenzyls, stilbenes, and phenanthrenes from C. caffrum.Some of the stilbenes proved to be potent antimitotic agents which inhibited both tubulin polymerization and the binding of colchicine to tubulin.Combretastatin A-4 has been shown to be the most potent cancer cell growth inhibitor of the series.Presently this cis-stilbene is the most effective inhibitor of colchicine binding to tubulin and the simplest natural product yet described with such potent antitubulin effects.Combretastatin A-4, A-5, and A-6 were also found to inhibit growth of Neisseria gonorrhoeae.Details of the isolation and syntheses of combretastatins A-4 (2a), A-5 (2c), and A-6 (3a) have been described.
View MoreLIANYUNGANG YC FINE CHEMICAL CO., LTD
Contact:+86-518-858 99188
Address:Shangdong Modern Bldg, South Greenpark Road, Lianyungang, Jiangsu Pro. China
HUNAN CHEMAPI BIOLOGICAL TECHNOLOGY CO.,LTD.
Contact:+86-186-02659358
Address:1004, building 3, Wanke Jinsemaitianyuan, 498 Guitang Road, Yuhua District, Changsha City, Hunan Province, China
website:http://www.enbridgepharm.com
Contact:+86-510-83591909
Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China
Weifang Jahwa Chemical Co.,Ltd
Contact:0086-536-8897731,8897730
Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
Qingdao Kylin Trading Co., Ltd.
Contact:0086-532-68979884/58972912/68972263/65/88171519
Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Doi:10.1021/ol0342913
(2003)Doi:10.1107/S0108270113009487
(2013)Doi:10.1021/om030392t
(2003)Doi:10.1021/jm00311a047
(1968)Doi:10.1021/jo00118a028
(1995)Doi:10.1007/s11164-019-03859-4
(2019)