Journal of Medicinal Chemistry p. 1666 - 1672 (1995)
Update date:2022-08-03
Topics:
Pettit, George R.
Singh, Sheo Bux
Boyd, Michael R.
Hamel, Ernest
Pettit, Robin K.
et al.
The antineoplastic constituents of Combretum caffrum (Eckl. and Zeyh) Kuntze (Combretaceae family), a species indigenous to South Africa, have been investigated.Subsequently we isolated a series of closely related bibenzyls, stilbenes, and phenanthrenes from C. caffrum.Some of the stilbenes proved to be potent antimitotic agents which inhibited both tubulin polymerization and the binding of colchicine to tubulin.Combretastatin A-4 has been shown to be the most potent cancer cell growth inhibitor of the series.Presently this cis-stilbene is the most effective inhibitor of colchicine binding to tubulin and the simplest natural product yet described with such potent antitubulin effects.Combretastatin A-4, A-5, and A-6 were also found to inhibit growth of Neisseria gonorrhoeae.Details of the isolation and syntheses of combretastatins A-4 (2a), A-5 (2c), and A-6 (3a) have been described.
View MoreShangHai BMG Chemical Co., Ltd
Contact:+86-13524845543
Address:Room 602, no 291 sikai road shanghai
Xinxiang Junlong Biological Technology Co., Ltd.
website:https://junlongbio.lookchem.com/
Contact:86-13525059581
Address:Xinxiang City, Henan Province
Contact:410-273-7300; 800-221-3953
Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA
website:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Shanghai Mokai Pharmaceutical Co.,Ltd
Contact:021-60257269
Address:Rm506,No.915,Zhenbei Road,Shanghai,200333,China
Doi:10.1021/ol0342913
(2003)Doi:10.1107/S0108270113009487
(2013)Doi:10.1021/om030392t
(2003)Doi:10.1021/jm00311a047
(1968)Doi:10.1021/jo00118a028
(1995)Doi:10.1007/s11164-019-03859-4
(2019)