Time-resolved ligand exchange reactions: Kinetic models for competitive inhibitors with recombinant human renin

DOI: 10.1021/jm00010a019

Source and publish data:

Journal of Medicinal Chemistry p. 1751 - 1761 (1995)

Update date:2022-08-03

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Authors:

Morelock

Pargellis

Graham Graham

Lamarre Lamarre

Jung Jung

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Article abstract of DOI:10.1021/jm00010a019

The on and off rate constants (k(on) and k(off)) were determined for a series of peptidomimetic, competitive inhibitors of human renin using a novel binding assay. The method entails analyzing a pair of ligand exchange reactions in which a dansylated inhi

Full text of DOI:10.1021/jm00010a019

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