Studies on a novel, potent and orally effective cholecystokinin A antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds

DOI: 10.1248/cpb.42.2071

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2071 - 2083 (1994)

Update date:2022-07-30

Topics:

Authors:

Satoh Satoh

Matsuo Matsuo

Sogabe Sogabe

Itoh Itoh

Tada Tada

Kinoshita

Yoshida Yoshida

Takaya Takaya

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Article abstract of DOI:10.1248/cpb.42.2071

We prepared various novel tricyclic 1,4-benzodiazepine derivatives as cholecystokinin (CCK) A antagonists, which were evaluated preliminarily for inhibition of ¹²⁵I-CCK-8 binding to rat pancreatic membranes in vitro and inhibiting effect on CCK

Full text of DOI:10.1248/cpb.42.2071

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Product name:(3,4-Dihydro-2H-benzo[1,4]thiazin-5-yl)-(2-fluoro-phenyl)-methanone

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