Helvetica Chimica Acta p. 486 - 504 (1995)
Update date:2022-08-03
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Martin
A general access to 2'-O-alkylated ribonucleosides using the key intermediate 5 is presented. The incorporation of 2'-O-'ethyleneglycol'- and 2'-O-'glycerol'-substituted (i.e., 2'-O-(2-hydroxyethyl)- and 2'-O-(2,3-dihydroxypropyl)-substituted) ribonucleosides into oligonucleotides affords a new generation of oligonucleotides with high affinity for RNA, high specificity, and increased nuclease resistance.
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Doi:10.1021/jm00013a017
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(1995)Doi:10.1016/0031-9422(94)00693-N
(1995)Doi:10.1002/anie.201402961
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