Paper
NJC
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methide in the presence of NaAuCl3Á2H2O to give the resultant
final product 4aa.
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Conclusions
In summary, we developed a novel Au-catalysed synthesis of
diarylindolylmethane from 2-ethynylanilines and p-quinone
methides via a tandem-type cyclization followed by 1,6-conjugative
addition. Subsequently, chemoselective conjugative addition to
C–C bond formation with p-quinone methide, in which the
aldehyde groups in 4aj and 4ak remain unreactive, leads to
excellent yields. We are extending this protocol to the construc-
tion of other poly aromatic compounds, the details of which
will be reported in due course.
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Conflicts of interest
There are no conflicts to declare.
Acknowledgements
This work was supported by a grant from the National Research
Foundation of Korea (NRF), funded by the Korean Government,
through the Center for New Directions in Organic Synthesis
(NRF-2014R1A5A1011165).
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