Novel 2,4-Diamino-5-Substituted-pyrrolopyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases

Article abstract of DOI:10.1021/jm00012a016

Eight novel, nonclassical, antifolate 2,4-diamino-5-(anilinomethyl)pyrrolo<2,3-d>pyrimidines, 1-8, with 3',4',5'-trimethoxyphenyl, 3',4'-dimethoxyphenyl, 2',5'-dimethoxyphenyl, 4--methoxyphenyl, 2',5'-diethoxyphenyl, 3',4'-dichlorophenyl, 1'-naphthyl, and