Novel 2,4-Diamino-5-Substituted-pyrrolopyrimidines as Classical and Nonclassical Antifolate Inhibitors of Dihydrofolate Reductases

DOI: 10.1021/jm00012a016

Source and publish data:

Journal of Medicinal Chemistry p. 2158 - 2165 (1995)

Update date:2022-09-26

Topics:

Authors:

Gangjee, Aleem

Mavandadi, Farahnaz

Queener, Sherry F.

McGuire, John J.

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Article abstract of DOI:10.1021/jm00012a016

Eight novel, nonclassical, antifolate 2,4-diamino-5-(anilinomethyl)pyrrolo<2,3-d>pyrimidines, 1-8, with 3',4',5'-trimethoxyphenyl, 3',4'-dimethoxyphenyl, 2',5'-dimethoxyphenyl, 4--methoxyphenyl, 2',5'-diethoxyphenyl, 3',4'-dichlorophenyl, 1'-naphthyl, and

Full text of DOI:10.1021/jm00012a016

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