European Journal of Medicinal Chemistry p. 415 - 421 (1995)
Update date:2022-09-26
Topics:
Claudi
Cingolani
Giorgioni
Cardellini
Amenta
Polidori
In order to determine whether the pyridine nucleus could replace the catechol moiety of the neurotransmitter dopamine or the phenol ring of the dopaminergic pharmacophore m-hydroxyphenylethylamine, the 2-(3-pyridyl)ethylamine 7, 2-(4-pyridyl)ethylamine 8, 2-(2-hydroxy-4-pyridyl)ethylamine 10 and their N,N-di-n-propyl- and N-n-propyl-N-2-phenylethyl derivatives were synthesized. The affinities of the new compounds for D1 and D2 dopamine receptors were evaluated by displacement of [3H]SCH 23390 (D1 selective) and [3H]spiperone (D2 selective) on rat neostriatum sections. The 2-(4-pyridyl)ethylamine 8 and its N,N-di-n-propyl derivative 18 showed the same affinity for the D1 and D2 receptors. Other compounds bound to the D1 receptor with higher affinity than to the D2 receptor. The possibility that the above compounds act as agonists and antagonists at the dopamine D1 and D2 receptors is discussed on the basis of guanosine-5'-triphosphate and Na+ displacement curves.
View MoreShenZhen InnoSyn Biotech Co.,Ltd
website:http://www.innosyns.com
Contact:+86-755-28351685
Address:Floor 5 & 6, Building A1, HAIKEXING Strategic Innovative Industrial Park, 16 BaoShan Road, PingShan District
Yantai Derun Liquid Crystal Materials Co. Ltd.
website:http://www.ytderun.com
Contact:86-535-6300169
Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI
Synchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong,Yuandong Road Fengxian District, Shanghai ,China
Jinhua City Mingzhu Pharmaceutical Co.,Ltd.
Contact:15857995878 0579-82207761
Address:No.169 Shenze Road, New Area,Jinpan Development Zone, Jinhua
ShanDong XinDa Chemical CO.,LTD(expird)
Contact:086-0311-87580543
Address:No.168, High Technology Development Zone Jinan Shandong China
Doi:10.1016/0277-5387(95)00141-E
(1995)Doi:10.1016/0040-4039(95)01273-K
(1995)Doi:10.1039/d0ob01151g
(2020)Doi:10.1021/jm00041a014
(1994)Doi:10.1021/jo00116a027
(1995)Doi:10.1016/0040-4039(94)88270-3
(1994)