Pyridonecarboxylic acids as antibacterial agents. IX. Synthesis and structure-activity relationship of 3-substituted 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] -1,4-benzoxazine-6-carboxylic acids and their 1-thio and 1-aza anal

DOI: 10.1248/cpb.42.2569

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2569 - 2574 (1994)

Update date:2022-07-31

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Authors:

Todo Todo

Takagi Takagi

Iino Iino

Fukuoka Fukuoka

Takahata

Okamoto Okamoto

Saikawa Saikawa

Narita Narita

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Article abstract of DOI:10.1248/cpb.42.2569

A series of the title compounds listed in Chart 1 have been synthesized to study the effects of 3-alkyl substituents on the antibacterial potency and in vivo efficacy of 10-(1-aminocyclopropyl)-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de] -1,4-benzoxazi

Full text of DOI:10.1248/cpb.42.2569

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