A practical synthetic method for 3-(N,N-disubstituted carbamoyloxy)methyl cephems without generating the Δ2-isomers

DOI: 10.1248/cpb.43.1031

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1031 - 1034 (1995)

Update date:2022-07-31

Topics:

Authors:

Negi Negi

Yamanaka

Komatsu Komatsu

Tsuruoka

Kamada Kamada

Tsukada Tsukada

Machida Machida

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Article abstract of DOI:10.1248/cpb.43.1031

E1101, a new oral cephalosporin, has a (N,N-dimethylcarbamoyloxy)methyl group at the C-3 position of the cephem nucleus. The previous methods for manufacturing 3-(N,N-disubstituted carbamoyloxy)methyl cephems generate various amounts of intractable Δ

Full text of DOI:10.1248/cpb.43.1031

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