Design and synthesis of N-alkylated saccharins as selective α-1a adrenergic receptor antagonists

DOI: 10.1016/S0960-894X(98)00446-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2467 - 2472 (1998)

Update date:2022-08-05

Topics:

Authors:

Nerenberg, Jennie B.

Erb, Jill M.

Thompson, Wayne J.

Lee, Hee-Yoon

Guare, James P.

Munson, Peter M.

Bergman, Jeffrey M.

Huff, Joel R.

Broten, Theodore P.

Chang, Raymond S. L.

Chen, Tsing B.

O'Malley, Stacey

Schorn, Terry W.

Scott, Ann L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00446-6

Benign prostatic hyperplasia can be managed pharmacologically with α-1 adrenergic receptor antagonists. Agents that demonstrate selectivity for the α-la receptor subtype may offer advantages in clinical applications with respect to hypotensive side effect

Full text of DOI:10.1016/S0960-894X(98)00446-6

Products guided by the article

Product name:Methyl-4-methyl-3-sulfamoylphenylsulfon

Cas No:1671-20-1

R&D Labs maybe for 1671-20-1

Hotechem Shanghai Co., Ltd

Contact:13120882795；+86-21-34621078;+86-021-31122318

Address:Suite 2,No.2715 Longwu Road
Dongguan Albiya Energy Science and Technology Co.,Ltd

Contact:+86-769-22181286

Address:Huanan Industial Park, Dongguan,China
Shanghai FWD Chemicals ltd

website:http://www.fwdchem.com

Contact:86-21-54450828

Address:Room 802,Lotus Tower ,159 Tianzhou Road,Xuhui District,Shanghai
jiangsu senxuan pharmaceutical and chemical co.,ltd

Contact:86-523-87982810

Address:hongqiao industrial zone,taixing,jiangsu china
Zhangjiagang Golden Reach Fine Chemical Co.,LTD.

Contact:+86-512-6585 6968

Address:Changfu Road， Dongsha Chemical Industry Park, Zhangjiagang City, Jiangsu Province, China

Relevant to this article

Doi:10.1021/jo01271a045
(1968)
Nucleophilic Additions to the Chiral Rhenium Alkene Complexes 5-C5H5)(NO)(PPh3)(H2C=CHR)>BF4 (R = H, Me, CH2CH2Me, Ph or CH2Ph): Regio-, Diastereo- and Enantio-selectivities

Doi:10.1039/DT9950001857
(1995)
Reaction of N-halosulfonamide. IV. A cleavage reaction of ether with N,N-dihalobenzenesulfonamide. (1).

Doi:10.1248/cpb.15.1331
(1967)
Doi:10.1039/j39670002700
(1967)
Doi:10.1016/S0040-4039(00)72432-4
(1973)
An improved synthesis and resolution of (±)-cis,cis-2,2'-spirobiindane-1,1'-diol

Doi:10.1016/0957-4166(95)00201-Y
(1995)

Article Doi