An improved synthesis and resolution of (±)-cis,cis-2,2'-spirobiindane-1,1'-diol

DOI: 10.1016/0957-4166(95)00201-Y

Source and publish data:

Tetrahedron Asymmetry p. 1575 - 1583 (1995)

Update date:2022-08-05

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Authors:

Nieman Nieman

Keay Keay

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Article abstract of DOI:10.1016/0957-4166(95)00201-Y

(±)-cis,cis-2,2'-spirobiindane-1,1'-diol (1) is synthesized stereoselectively in four steps beginning with 1-indanone in 68% overall yield. An improved resolution of diol 1 is described by preparing and separating diastereomeric mono-esters of 1 using (2S)-O-(tert-butyldimethylsilyl)mandeloyl chloride (10).

Full text of DOI:10.1016/0957-4166(95)00201-Y

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Product name:2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)phenylmethyl)-1-indanone

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