Identification and chemical synthesis of MDL 105,212, a non-peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors

Article abstract of DOI:10.1016/0960-894X(96)00148-5

We have synthesized and identified MDL 105,212, a non-peptide tachykinin receptor antagonist that has high affinity for human NK₁ ((IC₅₀ = 3.11 nM) and NK₂ (IC₅₀ = 8.40 nM) receptors. The chemical synthesis of M