Synthesis of the 2β,3α- and 2β,3β-Isomers of 3-(p-substituted phenyl)tropane-2-carboxylic Acid Methyl Esters

Article abstract of DOI:10.1016/0040-4039(95)00477-T

The synthesis of 3-(p-substituted phenyl)trop-2-ene-2-carboxylic acid methyl ester 8 and its reduction with samarium iodide provide a new synthesis of 3β-(4'-substituted phenyl)tropane-2β-carboxylic acid methyl ester (2) and, in addition, give the first s