Imidazopyridazines. XVIII. Syntheses and Central Nervous System Activities of Some 6-, 7- and 8-(Chloro and methoxy)imidazopyridine Analogues

Article abstract of DOI:10.1071/CH9951031

Syntheses are reported for some 2-aryl-3-(benzamidomethyl and methoxy)-6(7 and 8)-chloro- and 6(and 8)-methoxy-imidazo<1,2-a>pyridines.In tests of the ability of these compounds to displace <3H>diazepam from rat brain membrane, those with 6-chloro and 6-methoxy groups bound most strongly, and relatively small differences only were observed between corresponding imidazo<1,2-a>pyridines and imidazo<1,2-b>pyridazines.