Synthesis of 3-aminorhodanine derivatives as aldose reductase inhibitors

Article abstract of DOI:10.1002/jhet.5570320358

A number of 5-condensated 3-acylaminorhodanines 3 was prepared as potential inhibitors of the aldose reductase by acylation of the amino group of 3-aminorhodanine 1 and subsequent condensation of the 5-methylene function with appropriate aldehydes. Some of these compounds displayed interesting activity.