Chemoenzymatic approach to the AB ring system of Aklavinone

Article abstract of DOI:10.1016/S0040-4039(00)61382-5

Both enantiomers of compound 3, a possible intermediate for the AB ring system 2 of Aklavinone 1, were obtained in optically active form from diol 7. Key steps were the preparation of both enantiomers of monoacetate 8d, via enzymatic reactions that utiliz