Bioorganic and Medicinal Chemistry p. 101 - 113 (1997)
Update date:2022-08-03
Topics:
Njoroge, F. George
Doll, Ronald J.
Vibulbhan, Bancha
Alvarez, Carmen S.
Bishop, W. Robert
Petrin, Joanne
Kirschmeier, Paul
Carruthers, Nicholas I.
Wong, Jesse K.
Albanese, Margaret M.
Piwinski, John J.
Catino, Joseph
Girijavallabhan
Ganguly, Ashit K.
A comprehensive structure-activity relationship (SAR) study of novel tricyclic amides has been undertaken. The discovery of compounds that are potent FPT inhibitors in the nanomolar range has been achieved. These compounds are nonpeptidic and do not contain sulfhydryl groups. They selectively inhibit farnesyl protein transferase (FPT) and not geranylgeranyl protein transferase-1 (GGPT-1). They also inhibit H-Ras processing in Cos monkey kidney cells.
View MoreContact:+1-973-357-0577
Address:10 Taft Rd.
Jinan Jiaquan Chemical Co.,Ltd
Contact:+86-531-62318366
Address:Room 502 of Yidonghuayuan No.601 Huaxin Road Licheng District Jinan China
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Jiangxi Hito Chemical Co., Ltd.
Contact:+86-792-3170318
Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
RongCheng K&S Chemical Co.,Ltd
Contact:0631-7336369
Address:rongcheng ,shandong province china
Doi:10.1021/ic50056a034
(1967)Doi:10.1021/acscatal.7b03303
(2018)Doi:10.1002/anie.201910734
(2019)Doi:10.1021/ol3022897
(2012)Doi:10.1021/jo01273a017
(1968)Doi:10.1016/0022-328X(95)00326-L
(1995)
