Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzocycloheptene and Dibenzooxepin Derivatives. Searching for Bioisosteres of Biphenylyltetrazole Using a Three-Dimensional Search Technique

DOI: 10.1021/jm00014a024

Source and publish data:

Journal of Medicinal Chemistry p. 2728 - 2741 (1995)

Update date:2022-09-26

Topics:

Authors:

Kiyama, Ryuichi

Honma, Tsunetoshi

Hayashi, Kunio

Ogawa, Masayoshi

Hara, Mariko

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00014a024

Three-dimensional substructure searching (3D search), using the program MACCS-3D, was utilized for designing novel angiotensin II receptor antagonists which contain a bioisostere of the biphenylyltetrazole moiety of DuP 753.A 3D query was prepared from an

Full text of DOI:10.1021/jm00014a024

Products guided by the article

Product name:5-nitro-2-(m-tolyloxy)benzaldehyde

Cas No:169270-64-8

R&D Labs maybe for 169270-64-8

Longhui qunfeng Chemical Co., Ltd

Contact:86-731-82173407

Address:South-east Industrial Park, Longhui County, Hunan Province, China
Exploiter Molybdenum Co.,Ltd

Contact:86-379-63338609

Address:Jiudian Village,Deting Town,Song County,Luoyang
HAINAN JINYING IMPORT AND EXPORT CO. LTD

Contact:+86-898-32875423

Address:A SECTION 19TH FL, TIMES SQUARE, NO.2 GUO MAO AVENUE HAIKOU, HAINAN, P. R. OF CHINA
Taixing Joxin Bio-tec Co.,Ltd.

website:http://www.joxbio.com

Contact:86-523-87558858 87612088

Address:No.88, chengdong industrial park
HUNAN OUYA BIOLOGICAL CO.,LTD

Contact:+8613400661290

Address:No 908,Kangwan Rd, Liuyang Economic

Relevant to this article

Doi:10.1021/ja01651a031
(1953)
Synthesis and receptor binding of 5-amino[³H]₂methyl-3-isothiazolol ([³H]thiomuscimol), a specific GABA(A) agonist photoaffinity label

Doi:10.1002/jlcr.2580360909
(1995)
Doi:10.1016/0040-4020(73)80100-0
(1973)
Synthesis of Enantiomerically Pure cis and trans-2-Amino-1-indanol

Doi:10.1016/0957-4166(95)00192-R
(1995)
Doi:10.1021/ja01167a032
(1950)
Cyclooctadienyl Complexes of Molybdenum: Synthesis and η⁵ -> η³ Hapticity Interconversion

Doi:10.1039/DT9950002915
(1995)

Article Doi