Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzocycloheptene and Dibenzooxepin Derivatives. Searching for Bioisosteres of Biphenylyltetrazole Using a Three-Dimensional Search Technique

DOI: 10.1021/jm00014a024

Source and publish data:

Journal of Medicinal Chemistry p. 2728 - 2741 (1995)

Update date:2022-09-26

Topics:

Authors:

Kiyama, Ryuichi

Honma, Tsunetoshi

Hayashi, Kunio

Ogawa, Masayoshi

Hara, Mariko

et al. et al.

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Article abstract of DOI:10.1021/jm00014a024

Three-dimensional substructure searching (3D search), using the program MACCS-3D, was utilized for designing novel angiotensin II receptor antagonists which contain a bioisostere of the biphenylyltetrazole moiety of DuP 753.A 3D query was prepared from an

Full text of DOI:10.1021/jm00014a024

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Article Doi

Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzocycloheptene and Dibenzooxepin Derivatives. Searching for Bioisosteres of Biphenylyltetrazole Using a Three-Dimensional Search Technique

DOI: 10.1021/jm00014a024

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jm00014a024

Full text of DOI:10.1021/jm00014a024

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Synthesis and receptor binding of 5-amino[3H]2methyl-3-isothiazolol ([3H]thiomuscimol), a specific GABA(A) agonist photoaffinity label

Synthesis of Enantiomerically Pure cis and trans-2-Amino-1-indanol

Cyclooctadienyl Complexes of Molybdenum: Synthesis and η5 -> η3 Hapticity Interconversion

Synthesis and receptor binding of 5-amino[³H]₂methyl-3-isothiazolol ([³H]thiomuscimol), a specific GABA(A) agonist photoaffinity label

Cyclooctadienyl Complexes of Molybdenum: Synthesis and η⁵ -> η³ Hapticity Interconversion