A Stereoselective Route to 1-Chloro-1-halo-Enynes, Versatile Precursors for the Synthesis of Chloroenediynes and Enetriynes

Article abstract of DOI:10.1016/0040-4039(95)00612-G

1-Chloro-1-halo-enynes, readily available by metallation of (E)-chloroenynes, undergo sequential coupling with terminal alkynes under Pd-catalysis to produce stereoselectively chloroenediynes and enetriynes in good yields.Keywords: Palladium, chloroenyne, 1-chloro-1haloenyne, α-substituted chloroenyne, chloroenediyne, enetriyne