Bioorganic and Medicinal Chemistry Letters p. 2451 - 2454 (1997)
Update date:2022-08-04
Topics:
Sato, Masakazu
Manaka, Akira
Kawashima, Yutaka
Tomisawa, Kazuyuki
Iwata, Chuzo
A synthesis of both enantiomers of bio-active metabolite of 0N-579; 4-[2-(4-chlorophenyl- sulfonylamino)-ethylsulfinyl]-2,6-difluorophnoxyacetic acid was accomplished by the asymmetric oxidation of 0N-579 methyl-ester followed by hydrolysis. Difference in TXA2 receptor antagonizing activity was noted for the enantiomers in an U46619-induced rabbit platelet aggregation inhibitory activity.
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