Bioorganic and Medicinal Chemistry Letters p. 2451 - 2454 (1997)
Update date:2022-08-04
Topics:
Sato, Masakazu
Manaka, Akira
Kawashima, Yutaka
Tomisawa, Kazuyuki
Iwata, Chuzo
A synthesis of both enantiomers of bio-active metabolite of 0N-579; 4-[2-(4-chlorophenyl- sulfonylamino)-ethylsulfinyl]-2,6-difluorophnoxyacetic acid was accomplished by the asymmetric oxidation of 0N-579 methyl-ester followed by hydrolysis. Difference in TXA2 receptor antagonizing activity was noted for the enantiomers in an U46619-induced rabbit platelet aggregation inhibitory activity.
View MoreShanghai Dano Pharmaceutical Co.,Ld.(expird)
Contact:+86-592-6266840
Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China
Zhejiang Tianyu Pharmaceutical Co., Ltd.
Contact:+86-576-84177669, 89189665,89189688,84168770
Address:Jiangkou Development Zone, Huangyan, Taizhou City, Zhejiang
ZiBO KuoDing Trade company Ltd
website:http://www.sdzbkd.com
Contact:86-13361591822
Address:GongQingTuan road
Shenzhen Hongyuan Import & Export Co., Ltd.
Contact:0755-26407171
Address:Shenzhen Hongyuan Chemical New Materials Technology Co., Ltd.
Changzhou naidechemical Co.Ltd
Contact:+86-519-82589807
Address:NO.25,Houyang street,Jintan,Changzhou City
Doi:10.1039/c3ra46198j
(2014)Doi:10.1016/S0957-4166(00)80404-8
(1994)Doi:10.1039/c7gc03514d
(2018)Doi:10.1021/ja00101a011
(1994)Doi:10.1016/S0040-4020(01)81549-0
(1993)Doi:10.1016/j.bmcl.2013.12.095
(2014)
