Bioorganic and Medicinal Chemistry Letters p. 2451 - 2454 (1997)
Update date:2022-08-04
Topics:
Sato, Masakazu
Manaka, Akira
Kawashima, Yutaka
Tomisawa, Kazuyuki
Iwata, Chuzo
A synthesis of both enantiomers of bio-active metabolite of 0N-579; 4-[2-(4-chlorophenyl- sulfonylamino)-ethylsulfinyl]-2,6-difluorophnoxyacetic acid was accomplished by the asymmetric oxidation of 0N-579 methyl-ester followed by hydrolysis. Difference in TXA2 receptor antagonizing activity was noted for the enantiomers in an U46619-induced rabbit platelet aggregation inhibitory activity.
View MoreJiangxi Dongbang Pharmaceutical Co., Ltd.
Contact:+86-795-4433603, 4433388
Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C
Guangzhou Swan Chemical Co., Ltd.
Contact:+86-20-31075659
Address:NO.301, Hong ba fang investment BLDG 1,Guan chong village,Shiqi town,Panyu district,Guangzhou
Tianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Heliosense Biotechnologies, Inc.
Contact:+86-592-5667290
Address:Xiamen Torch Hi-tech Zone Venture Weiye Building S506
Contact:+86-512-69561895
Address:No.111, Building A4, 218 Xinghu Street, Suzhou Industrial Park, P. R. China
Doi:10.1039/c3ra46198j
(2014)Doi:10.1016/S0957-4166(00)80404-8
(1994)Doi:10.1039/c7gc03514d
(2018)Doi:10.1021/ja00101a011
(1994)Doi:10.1016/S0040-4020(01)81549-0
(1993)Doi:10.1016/j.bmcl.2013.12.095
(2014)
