Bioorganic and Medicinal Chemistry Letters p. 2323 - 2328 (1996)
Update date:2022-09-26
Topics:
Frueh
Saika
Svensson
Pitterna
Sakaki
Okada
Urade
Oda
Fujitani
Takimoto
Yamamura
Inui
Makatani
Takai
Umemura
Teno
Toh
Hayakawa
Murata
Combination of a glycine substitution scan on the C-terminal dodecapeptide analog of ET-1 and a substance P antagonist screen on the basis of a homology study of the rhodopsin superfamily of seven-transmembrane receptors yielded in the development of IRL 2500, a potent ET(B) selective endothelin antagonist.
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Doi:10.1016/S0022-328X(00)83172-1
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(1996)
