IRL 2500: A potent ET(B) selective endothelin antagonist

DOI: 10.1016/0960-894X(96)00421-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2323 - 2328 (1996)

Update date:2022-09-26

Topics:

Authors:

Frueh Frueh

Saika Saika

Svensson

Pitterna

Sakaki Sakaki

Okada Okada

Urade Urade

Oda Oda

Fujitani

Takimoto

Yamamura

Inui Inui

Makatani

Takai Takai

Umemura Umemura

Teno Teno

Toh Toh

Hayakawa

Murata Murata

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Article abstract of DOI:10.1016/0960-894X(96)00421-0

Combination of a glycine substitution scan on the C-terminal dodecapeptide analog of ET-1 and a substance P antagonist screen on the basis of a homology study of the rhodopsin superfamily of seven-transmembrane receptors yielded in the development of IRL 2500, a potent ET(B) selective endothelin antagonist.

Full text of DOI:10.1016/0960-894X(96)00421-0

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