Synthesis of 5'-C-methyl-D-allo- and L-talo-ribonucleoside 3'-O- phosphoramidites and their incorporation into hammerhead ribozymes

Article abstract of DOI:10.1080/15257779508012498

5'-C-Methyl-D-allo and L-talo-ribonucleoside 3'-O-phosphoramidites were prepared from L-rhamnose in 13 and 15 steps respectively. Incorporation of L-talo residues in the hammerhead ribozyme and the resulting activity and stability of the modified ribozyme

Full text of DOI:10.1080/15257779508012498

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Synthesis of 5′-C-Methyl-D-allo- & L-Talo-
ribonucleoside 3′-O-Phosphoramidites
& Their Incorporation into Hammerhead
Ribozymes
Leonid Beigelman a , Alexander Karpeisky a & Nassim Usman a
a Department of Chemistry & Biochemistry Ribozyme
Pharmaceuticals Inc. , 2950 Wilderness Place, Boulder, CO, 80301,
USA
Published online: 16 Feb 2007.
To cite this article: Leonid Beigelman , Alexander Karpeisky & Nassim Usman (1995) Synthesis of 5′-C-
Methyl-D-allo- & L-Talo-ribonucleoside 3′-O-Phosphoramidites & Their Incorporation into Hammerhead
Ribozymes, Nucleosides and Nucleotides, 14:3-5, 901-905
To link to this article: http://dx.doi.org/10.1080/15257779508012498
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