Synthesis of nucleoside 3′-phosphonates via 3′-keto nucleosides

Article abstract of DOI:10.1016/0040-4020(95)00363-D

Nucleophilic addition of diethyl phosphite anion to several 2′- or 3′-keto nucleosides results in an efficient synthesis of 2′-hydroxy-2′-phosphono- or 3′-hydroxy-3′-phosphononucleosides. The stereochemistry of one such adduct, 3′α-diethylphosphono-3′β-hy