2-chloro-2'-deoxyadenosine: Synthesis and antileukemic activity of 8- substituted derivatives

Article abstract of DOI:10.1080/15257779508010700

A series of 8-substituted 2-chloro-2'-deoxyadenosine (2-CdA, 1) derivatives were prepared as potential anticancer agents. They were synthesized stereoselectively by the anion glycosylation of 2,6,8- trichloropurine or obtained by nucleophilic displacement

Full text of DOI:10.1080/15257779508010700

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2-Chloro-2′-deoxyadenosine:
Synthesis and Antileukemic Activity of
8-Substituted Derivatives
Zygmunt Kazimierczuk b , Juhani A. Vilpo c & Frank Seela a
a Laboratorium für Organische und Bioorganische Chemie ,
Institut für Chemie, Universität Osnabrück , D-49069,
Osnabrück, Germany
b Department of Biophysics , University of Warsaw , PL-02089,
Warsaw, Poland
c Department of Clinical Chemistry , University of Tampere ,
SF-33520, Tampere, Finland
Published online: 24 Sep 2006.
To cite this article: Zygmunt Kazimierczuk , Juhani A. Vilpo & Frank Seela (1995) 2-Chloro-2′-
deoxyadenosine: Synthesis and Antileukemic Activity of 8-Substituted Derivatives, Nucleosides
and Nucleotides, 14:6, 1403-1414, DOI: 10.1080/15257779508010700
To link to this article: http://dx.doi.org/10.1080/15257779508010700
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