Chemical and Pharmaceutical Bulletin p. 699 - 702 (1995)
Update date:2022-08-04
Topics:
Kato
Morie
Yoshida
In order to confirm the proposed structures of two metabolites 3 and 4 of the gastroprokinetic agent mosapride [4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2 -morpholinyl]methyl}benzamide, 2], the compounds were synthesized and their biological activity was examined. The structures of the metabolites were confirmed by means of comparison with the synthetic compounds. The serotonin 5-HT4 receptor agonistic activities of the metabolites were found to be less than that of mosapride.
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Doi:10.1016/0040-4039(95)01805-R
(1995)Doi:10.1016/00404-0399(50)1355-L
(1995)Doi:10.1021/jo00129a021
(1995)Doi:10.1016/S0040-4020(98)83035-4
(1998)Doi:10.1016/j.ejmech.2017.01.031
(2017)Doi:10.1016/0031-9422(95)00458-J
(1995)
