Synthesis and Reactivity of a New Designed Molecule, 6,7-Benzobicyclotrideca-1,6,10-triene-3,8-diyn-5-one as a Pharmacophore of the Enediyne Antitumor Agents

DOI: 10.1016/0040-4039(95)00511-A

Source and publish data:

Tetrahedron Letters p. 3197 - 3200 (1995)

Update date:2022-08-04

Topics: Synthesis Reactivity Structural Analysis Biological Activity Safety and Toxicity

Authors:

Matsumoto, Yoshinori

Kuwatani, Yoshiyuki

Ueda, Ikuo

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Article abstract of DOI:10.1016/0040-4039(95)00511-A

A new designed tetradehydro<10>annulene quinomethide analogue 1, which is a simplified analogue having combined structural features of neocarzinostatin chromophore and golfomycin A, was prepared.Cycloaromatization of 1 and Micheal-type addition of thiol t

Full text of DOI:10.1016/0040-4039(95)00511-A

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