Diastereoselective addition of chiral aliphatic imines and 2-alkyl-1,3-oxazolidines to organometallic reagents

DOI: 10.1248/cpb.43.722

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 722 - 728 (1995)

Update date:2022-07-30

Topics: Mechanisms Examples

Authors:

Higashiyama

Fujikura

Takahashi

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Article abstract of DOI:10.1248/cpb.43.722

The reaction of organocerium reagents with chiral aliphatic imines derived from (R)-O-methylphenylglycinol afforded the corresponding amines with high diastereoselectivity. In contrast, the reaction of Grignard reagents with chiral 2-alkyl-1,3-oxazolidines derived from (R)-N-methylphenylglycinol afforded the amines with changeover in diastereoselectivity.

Full text of DOI:10.1248/cpb.43.722

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