Synthesis of lennoxamine via the intramolecular cyclization of alkynylamide

DOI: 10.1248/cpb.43.1604

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1604 - 1606 (1995)

Update date:2022-07-30

Topics:

Authors:

Koseki Koseki

Nagasaka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.1604

This paper presents the formal synthesis of lennoxamine (1), the key step [4 into 10 via 9] of which is a novel palladium-catalyzed coupling reaction followed by intramolecular cyclization of alkynylamide.

Full text of DOI:10.1248/cpb.43.1604

NII-Electronic Library Service

Products guided by the article

Product name:2-(2,2-dichlorovinyl)-5,6-dimethoxybenzoic acid

Cas No:171779-77-4

R&D Labs maybe for 171779-77-4

Nanjing Habo Medical Technology Co., Ltd.

Contact:025－85769882

Address:No.108. Ganjiabian east. Qixia District .Nanjing
Quhua Zhongxing Refrigeration Technology Co.,Ltd.

Contact:+86-5708886618

Address:318 Bulding 2, No.866 Quhua Rd.,Kecheng District
Anhui Eapearl Chemical Co., Ltd.

Contact:86-562-5858458

Address:358 South Huaihe Road
Chengdu Cogon Bio-tech Co., Ltd.

Contact:86-28-85171192

Address:NO.52.YongFeng Rd. Chengdu,610041,P.R.China.
NanJing KaiHeng Chemical CO., LTD.

Contact:+86-25-85768391

Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA

Relevant to this article

Enantiodivergent Synthesis of the Key Intermediate for Aphanorphine by Chemoenzymatic Process

Doi:10.1016/0040-4020(95)00784-6
(1995)
Synthesis, Antitumor Activity, and Chemical Properties of Silaplatin and Related Platinum(II) and Platinum(IV) Complexes Derived from β-Silyl Amines

Doi:10.1021/jm00019a008
(1995)
Conformational restriction by repulsion between adjacent substituents on a cyclopropane ring: Design and enantioselective synthesis of 1-phenyl-2-(1-aminoalkyl)-N,N-diethylcyclopropanecarboxamides as potent NMDA receptor antagonists

Doi:10.1021/jo9518056
(1996)
Azoles. Part 12. Synthesis of thieno-extended purines: First example of the imidazo[4′,5′:4,5]thieno[3,2-d]pyrimidine ring system

Doi:10.1016/0040-4020(95)00845-Y
(1995)
An Unexpected Reaction Between B(C6F5)3 and 5-C5H5)(CO)2Me> Gives <Me)>(η⁵-C5H5)(CO)>

Doi:10.1039/c39950001853
(1995)
The synthesis and structures of deuterium-labeled 5-substituted 1H-tetrazoles

Doi:10.1002/jlcr.1524
(2008)

Article Doi