Synthesis of lennoxamine via the intramolecular cyclization of alkynylamide

DOI: 10.1248/cpb.43.1604

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1604 - 1606 (1995)

Update date:2022-07-30

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Authors:

Koseki Koseki

Nagasaka

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Article abstract of DOI:10.1248/cpb.43.1604

This paper presents the formal synthesis of lennoxamine (1), the key step [4 into 10 via 9] of which is a novel palladium-catalyzed coupling reaction followed by intramolecular cyclization of alkynylamide.

Full text of DOI:10.1248/cpb.43.1604

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