Synthesis of lennoxamine via the intramolecular cyclization of alkynylamide

DOI: 10.1248/cpb.43.1604

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1604 - 1606 (1995)

Update date:2022-07-30

Topics:

Authors:

Koseki Koseki

Nagasaka

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.1604

This paper presents the formal synthesis of lennoxamine (1), the key step [4 into 10 via 9] of which is a novel palladium-catalyzed coupling reaction followed by intramolecular cyclization of alkynylamide.

Full text of DOI:10.1248/cpb.43.1604

NII-Electronic Library Service

Products guided by the article

Product name:2-(2,2-dichlorovinyl)-5,6-dimethoxybenzoic acid

Cas No:171779-77-4

R&D Labs maybe for 171779-77-4

Shandong Shouguang Songchuan Industrial Additives Co.,Ltd

Contact:+86-536-8566856

Address:Shouguang,Shandong,China
N&R INDUSTRIES,INC

Contact:Tel:+86-29-88764861 Fax:+86-29-88764861

Address:Rm#2107, Block A, Epin Meidao Building, Gaoxin Rd, Hi-Tech Zone, Xi’an, China
jiangsu hualin chemical co.,ltd.

Contact:86-25-87787402

Address:jaingsu,china
Beijing Tianjia Chemical Science & Technology Co.,Ltd

Contact:86-0550-2392698

Address:No.388, Shiliang Road (East),
MINS GROUP CO.,LIMITED

Contact:18669908765

Address:Zibo City, Shandong Province, P.R.China

Relevant to this article

Enantiodivergent Synthesis of the Key Intermediate for Aphanorphine by Chemoenzymatic Process

Doi:10.1016/0040-4020(95)00784-6
(1995)
Synthesis, Antitumor Activity, and Chemical Properties of Silaplatin and Related Platinum(II) and Platinum(IV) Complexes Derived from β-Silyl Amines

Doi:10.1021/jm00019a008
(1995)
Conformational restriction by repulsion between adjacent substituents on a cyclopropane ring: Design and enantioselective synthesis of 1-phenyl-2-(1-aminoalkyl)-N,N-diethylcyclopropanecarboxamides as potent NMDA receptor antagonists

Doi:10.1021/jo9518056
(1996)
Azoles. Part 12. Synthesis of thieno-extended purines: First example of the imidazo[4′,5′:4,5]thieno[3,2-d]pyrimidine ring system

Doi:10.1016/0040-4020(95)00845-Y
(1995)
An Unexpected Reaction Between B(C6F5)3 and 5-C5H5)(CO)2Me> Gives <Me)>(η⁵-C5H5)(CO)>

Doi:10.1039/c39950001853
(1995)
The synthesis and structures of deuterium-labeled 5-substituted 1H-tetrazoles

Doi:10.1002/jlcr.1524
(2008)

Article Doi