Synthesis, antiviral, antibacterial and antitumor cell activities of 2'-deoxy-2'-fluoropuromycin

DOI: 10.1248/cpb.43.955

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 955 - 959 (1995)

Update date:2022-09-26

Topics:

Authors:

Maruyama

Utsumi Utsumi

Tomioka Tomioka

Kasamoto

Sato Sato

Anne Anne

De Clercq

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Article abstract of DOI:10.1248/cpb.43.955

A procedure for the synthesis of 2'-deoxy-2'-fluoropuromycin (1b) was developed. Ring opening of the lyxo-epoxide (4) or nucleophilic displacement of the 3'-O-mesylate (5) by an azide ion afforded two azido nucleosides, 6a and 7a. The major product (7a) w

Full text of DOI:10.1248/cpb.43.955

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