Further evaluation of 5-alkyl-5-deaza antifolates. 5-Propyl- and 5-butyl-5-deaza analogues of aminopterin and methotrexate

Article abstract of DOI:10.1002/jhet.5570320419

5-Propyl-5-deaza and 5-butyl-5-deaza analogues of classical antifolates were synthesized by extensions of a previously reported general route which proceeds through 2,4-diamino-5-alkylpyrido[2,3-d]pyrimidine-6-carbonitrile intermediates followed by reduct