Synthesis and Selective Deprotection of the Penta-N-Protected Polyamine 1,16-Diamino-4,8,13-triazahexadecane

Article abstract of DOI:10.1016/0040-4020(95)00811-L

The synthesis of the penta-N-protected polyamine thermopentamine -carbamate>, containing five different N-protecting groups is described.These protecting groups include tert-butoxycarbonyl, benzyl, trifluoroacetyl, diallyl, and pyridine-2-sulfonyl.In spite of the syntheses of specific polyamine derivatives the selective removal of each of these groups has been investigated.