New solid phase synthesis of oligodeoxythymidine phosphorodithioates by a modified HObt-method

Article abstract of DOI:10.1016/0040-4039(95)01106-R

Two new dithiophosphorylating reagents 2a,b have been prepared and shown to give nucleoside monomers 3a,b with reactivities suitable for solid phase synthesis. An octamer and a nonamer deoxythymidine phosphorodithioate were prepared on a TentaGel support