2-Benzoylamino-6,7-dimethoxy-4H-3,1-benzoxazin-4-one: Synthesis and Investigation of Serine Protease Inactivation

Article abstract of DOI:10.1007/BF00811383

2-Benzoylamino-6,7-dimethoxy-4H-3,1-benzoxazin-4-one was prepared by thermal treatment of 2-(3-benzoylthioureido)-4,5-dimethoxybenzoic acid and by benzoylation of 2-amino-6,7-dimethoxy-4H-3,1-benzoxazin-4-one.The inactivation of chymotrypsin and human leukocyte elastase by the title compound and 2-benzoylamino-4H-3,1-benzoxazin-4-one is reported. - Keywords: 2-Benzoylamino-4H-3,1-benzoxazin-4-one; 2-(3-Benzoylthioureido)benzoic acids; Enzyme inactivation; Serine proteases