A novel solid support for synthesis of 3'-phosphorylated chimeric oligonucleotides containing internucleosidic methyl phosphotriester and methylphosphonate linkages

DOI: 10.1016/S0040-4039(97)00739-9

Source and publish data:

Tetrahedron Letters p. 3989 - 3992 (1997)

Update date:2022-08-03

Topics:

Authors:

Guzaev, Andrei

Loennberg, Harri

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Article abstract of DOI:10.1016/S0040-4039(97)00739-9

A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability

Full text of DOI:10.1016/S0040-4039(97)00739-9

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