A novel solid support for synthesis of 3'-phosphorylated chimeric oligonucleotides containing internucleosidic methyl phosphotriester and methylphosphonate linkages

Article abstract of DOI:10.1016/S0040-4039(97)00739-9

A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strategy on solid support 2, which allows a mild and fast release of the oligonucleotide in solution. The applicability