Journal of Organic Chemistry p. 10660 - 10667 (2015)
Update date:2022-08-04
Topics:
Zhang, Xinying
Wang, Zhangxin
Fan, Xuesen
Wang, Jianji
In this paper, a novel methodology for the synthesis of ketones via microwave irradiation promoted direct alkylation of aldehydes by activation of the inert C(sp3)-H bond has been developed. Notably, the reactions were accomplished under metal-free conditions and used commercially available aldehydes and cycloalkanes as substrates without prefunctionalization. By using this novel method, an alternative synthetic approach toward the key intermediates for the preparation of the pharmaceutically valuable oxaspiroketone derivatives was successfully established.
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