Synthesis and analgesic evaluation of some 1,1-disubstituted 3-carboxy-4-phenyl-1,2,3,4-tetrahydro- β-carboline derivatives

DOI: 10.1016/0223-5234(96)88272-9

Source and publish data:

European Journal of Medicinal Chemistry p. 575 - 586 (1995)

Update date:2022-07-29

Topics:

Authors:

Nagy Nagy

Jeannin Jeannin

Sapi Sapi

Laronze Laronze

Renard Renard

Pfeiffer

Bizot-Espiard

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Article abstract of DOI:10.1016/0223-5234(96)88272-9

New 4-phenyl-1,2,3,4-tetrahydro-β-carbolines were synthesized from β-phenyltryptophan ester. They were evaluated in induced pain on rodents. Amide 17b proved to be the most powerful in the series. Several compounds display significative antiinflammatory properties.

Full text of DOI:10.1016/0223-5234(96)88272-9

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