Rational Design and Synthesis of Small Molecule, Non-oligosaccharide Selectin Inhibitors: (α-D-Mannopyranosyloxy)biphenyl-Substituted Carboxylic Acids

DOI: 10.1021/jm00026a004

Source and publish data:

Journal of Medicinal Chemistry p. 4976 - 4984 (1995)

Update date:2022-07-29

Topics:

Authors:

Kogan, Timothy P.

Dupre, Brian

Keller, Karin M.

Scott, Ian L.

Bui, Huong

et al. et al.

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Article abstract of DOI:10.1021/jm00026a004

The calcium dependent E-selectin/sialyl Lewis^x (sLe^x) interaction plays a key role in inflammation where it mediates the rolling of leukocytes prior to firm adhesion and extravasation from the vasculature.A model of E-selectin/sLe View More

Full text of DOI:10.1021/jm00026a004

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