Journal of the Chemical Society. Perkin transactions I p. 2029 - 2039 (1996)
Update date:2022-08-05
Topics:
Jackson, P. Mark
Roberts, Stanley M.
Davalli, Silvia
Donati, Daniele
Marchioro, Carla
Perboni, Alcide
Proviera, Stefano
Rossi, Tino
Coupling the silyl enol ether 5 and the β-lactam 9 (R = Me3Si) affords the ketones 13a-d. Compounds 13a, 13c and 13d are converted into the tricyclic lactams 16-20, 23-25. (Chemoenzymatic synthesis of optically pure silyl enol ether 5 gave access to homochiral lactams 23-25.) In addition the ketoazetidinones 13 are protected as the 1,3-oxazanes 30. A hydroxyethyl moiety is introduced into these oxazanes at C-11 with the desired stereochemistry using the Bouffard methodology, to afford the alcohols 32. Formation of the corresponding nitrobenzyl carbonate, deprotection and oxidation furnishes the ketones 35a and 35b, which are subsequently converted into the trinems 41a and 41b, respectively.
View MoreContact:+86-0512-62857507
Address:Boji Science Park, No1688C,Taishan road, Suzhou ,China
Shenzhen HwaGen Pharmaceutical Co., Ltd
website:http://www.rafflespt.com
Contact:+86-752-5538396
Address:Guangdong Huizhou China
Goldwills Pharmaceuticals Co., Ltd.
Contact:0916-2237889 13991621155
Address:North Suburb of Hanzhong city, Shaanxi Province
Hangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Luojiang Chenming Biological Products Co
Contact:+86 15000297032
Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Doi:10.1016/0040-4020(67)85064-6
(1967)Doi:10.1021/ja00153a030
(1995)Doi:10.1002/hlca.19950780523
(1995)Doi:10.1021/ol005579k
(2000)Doi:10.1016/0277-5387(95)00188-X
(1996)Doi:10.1016/S0040-4020(01)82498-4
(1968)
