Monocyclic Analogues of the μ-Opioid Agonist 3,8-Diazabicyclooctanes: Synthesis, Modeling, and Activity

DOI: 10.1016/0040-4020(95)00716-L

Source and publish data:

Tetrahedron p. 11547 - 11556 (1995)

Update date:2022-09-26

Topics:

Authors:

Barlocco, Daniela

Villa, Stefania

Fratta, Walter

Fadda, Paola

Colombo, Diego

Toma, Lucio

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Article abstract of DOI:10.1016/0040-4020(95)00716-L

Several monocyclic derivatives structurally related to the μ-opioid agonist 3-cinnamyl-8-propionyl-3,8-diazabicyclo<3.2.1>octane have been synthesized and tested in binding studies using the μ-selective 3H-DAMGO as ligand.Modeling studies have been performed on the same compounds in order to explain the observed lack of affinity towards μ-opioid receptors.

Full text of DOI:10.1016/0040-4020(95)00716-L

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