A chemoenzymatic synthesis of A-ring key-intermediates for 1 α,25-dihydroxyvitamin D3 and analogues

Article abstract of DOI:10.1016/0040-4039(95)01902-T

A short and practical synthesis of the 1,7-enyne A-ring intermediate and of Uskokovic's phosphine-oxide precursor is described starting from the aldol product of acrolein with t-butyl acetate. Enantiopure βhydroxy ester is obtained upon lipase-catalyzed resolution.