A simple desymmetrisation approach to unsymmetric N,N'-disubstituted cyclic ureas

DOI: 10.1016/S0040-4039(99)01484-7

Source and publish data:

Tetrahedron Letters p. 7143 - 7146 (1999)

Update date:2022-07-30

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Authors:

Bew, Sean P.

Bull, Steven D.

Davies, Stephen G.

Eames, Jason

Baxter, Anthony D.

Mykytiuk, John

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Article abstract of DOI:10.1016/S0040-4039(99)01484-7

The bis-enolate derived from 1,3-di-isobutyryl-trans-4,5-tetramethylene- imidazolidin-2-one 8 is unstable and deacylates to afford dianion 11 which can be regioselectively alkylated to afford unsymmetric cyclic urea 17 in good yield. Subsequent deacylatio

Full text of DOI:10.1016/S0040-4039(99)01484-7

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