Nitrosation of methyl 2-acylamino-3-dimethylaminopropenoates. A simple conversion of N-acylglycines into 5-substituted 1,2,4-oxadiazole-3-carboxylates

Article abstract of DOI:10.1002/jhet.5570320525

A novel simple synthesis of 5-substituted-1,2,4-oxadiazole-3-carboxylates 5 from N-acylglycines 1, which are transformed with DMF in the presence of phosphorus oxychloride into 2-substituted-4-dimethylaminomethyleneoxazol-5(4H)-ones 2, followed by opening