Nitrilotriacetamide: Synthesis in concentrated sulfuric acid and stability in water

Article abstract of DOI:10.1080/00397919508011491

Acid hydrolysis of N(CH₂CN)₃ leads either nitrilotriacetamide, 1, and/or 3,5-dioxopiperazineacetamide, 4, in quantitative yield. 1 slowly and cleanly converts to 3,5-dioxopiperazineacetic acid, 5, in water, although ammonium salts prevents this reaction.

Full text of DOI:10.1080/00397919508011491

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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Nitrilotriacetamide: Synthesis
in Concentrated Sulfuric Acid
and Stability in Water
Douglas A. Smiths a b , Steven Sucheck b , Susan
Cramer b & David Baker b
a Department of Chemistry, The University of
Toledo, Toledo, OH, 43606-3390
b Concurrent Technologies Corporation, 1450 Scalp
Avenue, Johnstown, PA, 15904
Published online: 23 Sep 2006.
To cite this article: Douglas A. Smiths , Steven Sucheck , Susan Cramer & David Baker
(1995): Nitrilotriacetamide: Synthesis in Concentrated Sulfuric Acid and Stability in
Water, Synthetic Communications: An International Journal for Rapid Communication
of Synthetic Organic Chemistry, 25:24, 4123-4132
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