A novel and efficient synthesis of 14-alkoxy-substituted indolo- and benzofuromorphinans in the series of selective δ opioid receptor antagonists

Article abstract of DOI:10.1002/hlca.19980810532

A novel and more efficient synthesis of 14-alkoxy-substituted indolo- and benzofuro-morphinans in three steps starting from either naltrindole (1) or naltriben (2), using methoxymethyl or silyl protecting groups, is reported. The 14-O-alkyl group is intro