Total Synthesis of Polyamine Amide Spider Toxin Argiotoxin-636 by a Practical Reductive Alkylation Strategy

Article abstract of DOI:10.1016/0040-4039(95)01994-S

Reductive alkylation is a practical strategy for a total synthesis of spider toxin argiotoxin-636, a polyamine amide which is selective glutamate receptor antagonist and may have potential as a neuroprotective agent.Central to this synthesis are a Swern o