Synthesis of 2'-substituted sulfide-linked dinucleotides

Article abstract of DOI:10.1080/15257779508010717

3'-Deoxy-3'-(2-mesyloxyethyl)ribofuranosylthymine derivative 3, and its 2'-methoxy (16) and 2'-deoxy (38) analogs were condensed with 5'-deoxy-5'- thiothymidine 4 and 17 or 2'-O-methyl-5'-deoxy-5'-thiouridine 34 and 37 to provide, after standard functional group transformations, thymidine-thymidine and uridine-thymidine dimers 9, 21, 43 and 47. Oxidation of model sulfide dimer 48 with oxone gave sulfone 49. It was not stable to 27% ammonia.

Full text of DOI:10.1080/15257779508010717

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Nucleosides and Nucleotides
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Synthesis of 2′-Substituted Sulfide-
Linked Dinucleotides
Daguang Wang a , Bin Meng a , Masad J. Damha a & George Just a
a Department of Chemistry , McGill University , Montreal,
Québec, Canada , H3A 2K6
Published online: 24 Sep 2006.
To cite this article: Daguang Wang , Bin Meng , Masad J. Damha & George Just (1995) Synthesis
of 2′-Substituted Sulfide-Linked Dinucleotides, Nucleosides and Nucleotides, 14:9-10, 1961-1984,
DOI: 10.1080/15257779508010717
To link to this article: http://dx.doi.org/10.1080/15257779508010717
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