Methanocarba modification of uracil and adenine nucleotides: High potency of northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors

DOI: 10.1021/jm010369e

Source and publish data:

Journal of Medicinal Chemistry p. 208 - 218 (2002)

Update date:2022-08-02

Topics:

Authors:

Hak Sung Kim

Ravi Ravi

Marquez Marquez

Maddileti

Wihlborg

Erlinge Erlinge

Malmsj? Malmsj?

Boyer Boyer

Harden Harden

Jacobson

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Article abstract of DOI:10.1021/jm010369e

The potency of nucleotide antagonists at P2Y₁ receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J. Med. Chem. 2000, 43, 829-842). We have now synthesized ring-constrained methanocarba an

Full text of DOI:10.1021/jm010369e

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